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Researcher

Prominent New Theories

What the latest science and research tells us, helping  form the foundation of our programme.

We share the following information to help give you a glimpse of the various possibilities at your fingertips.

This page provides a general overview of some of the key developments and most prominent areas of research.
  • Although not an exhaustive list, these areas form the foundation of our programme. 

 

We hope you are able to see just how much control you have over your brain health and function through a variety of mechanisms.
  • The information below helps demonstrate what a powerful effect diet and lifestyle can play when it is applied specifically to these mechanisms.

  • This often provides many with some much needed hope that they can improve their current state, even if they've had drug therapy which didn't give them the results they were after.

 

We hope this information empowers you  to take back control over your brain health and function.​

Already the monoamine theory, from which the psychiatric system approach is currently built upon, is outdated. sufficeint flaws with drugs, more complex, more specific tools. sophistication

This theory focused on the cause of mental illness or brain disorders through the lens of brain chemicals.

  • This is most well known theory as it's what conventional medicine primarily focuses on.

  • You have likely been told the narrative that brain issues are the result of a chemical imbalance - these chemicals are your neurotransmitters.

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The basics in how your brain works and the role of your neurotransmitters.​

Neurotransmitters are a way in which your neurons communicate with one another.​
  • When neurons are activated, they pass an electrical current through them, and spit out a number of neurotransmitters.

  • These interact with a neighbouring neuron, and the communication is simply to increase or decrease the chance of the other neuron firing.

  • Depending on the net affect of the neurotransmitter signals, amongst other factors, the neuron either activates or not.

 

If neurons go on to activate one another, you can think of this as a domino  affect, and certain neuronal pathways are formed, with electricity passing through them.
  • The neurotransmitters released play an important role in influencing which pathways occur. 

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Depending on which neurons / pathways are being activated, this results in different functions / activities occurring, such as:
  • Providing a feeling or emotion.

  • Constructing a thought.

  • Initiating an action or behaviour.

  • Directing your attention / perception onto something.

  • Perceiving your senses such as taste, touch or sight.​

 

As a result, neurotransmitter activity greatly influences our brain function and the symptoms you may be experiencing.

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In conventional medicine, drugs are often provided to greatly influence 1 or 2 neurotransmitters to 'help bring them into balance.'

Depending on the diagnosis, different drugs may be prescribed, which tend to focus on a different combination of neurotransmitters.
  • For ADHD:

    • Stimulants are often provided, increasing levels of dopamine and norepinephrine.

  • For depression and anxiety:

    • SSRIs are provided to increase levels of serotonin.

    • Benzodiazepines may be used to increase the balance of GABA to glutamate.

  • For autism​:

    • Autism presentations vary greatly and there is no medication primarily focused on some of the key aspects of autism.​

    • That said, most do take at least one psychotropic medication due to many having other conditions in addition to autism:

      • SSRIs for depression and anxiety symptoms.​

      • Stimulants for ADHD symptoms.

      • Antipsychotic medications to help with irritability and aggression.

        • This reduces the activity of dopamine.​

  • Parkinsons:

    • A range of drugs can be used which primarily increase the activity of dopamine.

    • They may:

      • Increase the synthesis of dopamine, impact the dopamine receptor, or limit the breakdown of dopamine.​

  • Alzheimer's disease:

    • Cholinesterase inhibitors may be prescribed.

    • These prevent the breakdown of acetylcholine, therefore increasing its levels and activity.

The limited effectiveness of conventional medicine on brain disorders as well as the risks.

  • Although psychiatric drugs have certainly been beneficial for many people, this isn't always the case.

  • Many aren't seeing noticeable improvements on these medications.

  • Negative side affects are incredibly common.

  • Significant withdrawal symptoms can occur when coming off these medications.

  • Many remain on these medications for many years.

    • Far longer than they were designed and tested for, with potential long-term impacts to the brain which aren't fully understood.​​​​​

 

For more on the overall effectiveness and risks of these drugs, as well as the reasons behind these, these can be found with the "Limitations of Conventional Medicine" tab.​
  • As you may read, these are less promising than many are led to believe, with some concerning risks to be aware of.

1. Neurotransmitter Imbalance Theory

And the latest findings on neurodevelopmental /psychiatric drugs

The good news is we have a far greater understanding on what influences neurotransmitter levels and activity.

Billions has been spent on understanding how these neurotransmitters work and what affect they have.
  • Although much of this research is to help create a new and more effective drug, we can utilise the findings to discover the mechanisms in which nutritional and lifestyle components can influence these processes.

 

For example we now know the nutritional components in:
  • Making the neurotransmitters.

  • Influencing the receptors of these neurotransmitters.

  • The removal of the neurotransmitters from the synapse.

  • As well as how these are broken down.

 

In addition to this we know the other factors at play such as the importance of:
  • Mitochondrial health.

  • Inflammatory levels.

  • Toxins.

  • Hormones.

  • And many others.

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We are now in a position to work with your physiological systems for improving function, rather than against it with medications. 

  • For the first time we can start investigating why your neurotransmitter levels may be imbalanced, and work to restore these in a more harmonious manner.

  • The following sections will provide an overview of the key areas that are known to impact neurotransmitter levels and activity, as well as having other impacts on your neuronal health which can contribute to your individual symptoms.

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Already the monoamine theory, from which the psychiatric system approach is currently built upon, is outdated. sufficeint flaws with drugs, more complex, more specific tools. sophistication

​Nutrition provides the building blocks and cofactors for all the tissues and processes within the body.​

  • It should therefore be no surprise that nutrition directly plays a key role in your brain health and function, as well as being a key factor in all the various systems (immune system, endocrine system, etc.) which are also known to impact brain function.​

We are all biochemically individual.

  • Biochemistry explores the chemical processes happening within you.

  • Each of us have a body that functions due to these biochemical factors, influencing our mood, behaviours, personality, immune function, etc.

  • Despite us being more similar than we are different, when we delve into the realm of these biochemical processes, we have unique signatures.

    • Some of these processes work more smoothly than others.

  • This results in us reacting differently to the same inputs, and our nutritional and lifestyle needs will differ.

 

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Your bio-individuality comes from your genes, diet and lifestyle.

By producing proteins that control and regulate these processes, your genes can greatly influence these biochemical processes.
  • From a given set of parents, there’s over 42 million genetic variants a child can be born with, highlighting just how individual your genetic makeup is.

  • These genetic differences can influence how our bodies process foods and their components, resulting in severe deficiencies or excesses in certain nutrients, even with a healthy diet in some cases.

  • The good news is you have an influence on what genes turn on and off, and you can also negate some of the more ‘problematic’ genes with nutrition and lifestyle.

 

Both your diet and lifestyle can improve or dysregulate these processes.
  • Diet can provide the key nutrients to run these processes, or it can introduce problematic foods that cause stress on your system and draw on your nutrients in order to deal with this stress.

  • Your lifestyle can provide the right balance of demands and repair time to help build a resilient system.

  • Unfortunately there is a strong trend in a reduction of our diet quality, with less nutrients but more calories being consumed, as well as lifestyles that our chronically stressed.​

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Nutrient and biochemical imbalances are often at the root, or play a significant role in many brain related conditions.

The Walsh Research Institute has been at the forefront of ground-breaking research over the last 30 years.
  • Its mission has been to unravel the biochemistry of mental disorders and development of improved clinical treatments though scientific research.

  • It has analysed an unparalleled database of more than 3 million chemical assays, studying more than 30,000 patients with various mental disorders.

  • It discovered common nutritional and biochemical imbalances at play – often in areas that are known to impact neurotransmitter activity.

  • These imbalances varied between individuals even with the same symptoms, highlighting that different root causes can be at play.

  • More importantly, when correcting for these imbalances with the use of supplements, the  efficacy rates were outstanding, with the added benefit of no side effects or dependency issues with medications.​​​

During our programme you will:​

  • Have your symptoms and history assessed to help guide us on what imbalances you are likely to be experiencing.

  • Have the opportunity to undergo specific lab tests to confirm any imbalances.

  • Receive an understanding for the causes of these imbalances as well specific guidance on how to correct these imbalances, both with diet, supplements and lifestyle practices.

  • Have the option to re-test your levels to ensure these imbalances have been corrected.

Please read below for an overview of just some of the key imbalances often at play.​​

  • As you will see from their impacts, these imbalances are known to play key functions in your neurotransmitter levels and activity, helping explain the why behind your neurotransmitters being out of balance.

  • They also impact other key areas which can impact your brain function, and these will be further described in the later sections.

Copper and zinc imbalances

Copper and zinc can be viewed as a nutritionally seesaw.

  • If the level of one rises, the level of the other drops.

 

Despite both having vital roles within the brain, too much or too little of either is problematic.

  •  We commonly see issues with too much copper and too little zinc.

 

Copper overload can result in lower dopamine levels and increased norepinephrine in the brain.

  • This is due to the fact that copper coverts dopamine to norepinephrine.

  • This neurotransmitter imbalance is particularly associated with ADHD, behavioural problems, anxiety and neurodegeneration.

 

Copper overload can also increase oxidative stress.

  • Causing wear and tear in various tissues including the brain, as too much copper can be toxic.

 

Zinc deficiency has wide ranging issues due to zinc having specific roles in:

  • Early brain development.

  • Converting vitamin B6 to P5P, allowing it to complete it’s essential roles in neurotransmitter production.

  • Influencing the blood brain barrier – helping prevent harmful chemicals from entering the brain.

  • Combating oxidative stress.

  • Development and functioning of your immune system.

  • Manufacturing proteins and enzymes.

    • Proteins form the building blocks of nearly all cellular structures and enzymes control cellular activity processes. 

    • In other words, zinc is essential for the creation and operation of every cell in your body.

  • It also influences taste, smell and appetite; making it a key factor in those who are fussy eaters.

Methylation imbalances

Methylation is simply the transfer of a carbon-containing molecule to another molecule.

  • This may not sound too important, but this process happens to be of extraordinary importance in human functioning for both physical, mental, and emotional health.

  • This process is happening billions of times per second in every cell of the body.

 

Over two-thirds of people with mental health issues have a methylation imbalance.

  • According to the Walsh Research Institute.

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It has many different functions but some of its more salient functions include:

Regulating various neurotransmitters.

  • It influences serotonin and dopamine in the same way that psychiatric drugs work – by inhibiting the reuptake proteins, which results in a strong influence on neurotransmitter activity.

  • It is used to breakdown dopamine, norepinephrine, and epinephrine – all of which can be problematic if their levels become too high.

  • It is used to produce melatonin – a vital neurotransmitter in assisting with quality sleep.

  • It also helps regulate glutamate activity.

 

Regulating  gene expression.

  • Your genes contain instructions that your cells use to produce proteins. These proteins perform and control the huge variety of functions in your body.

  • Certain genes need to be ‘turned on or off” at certain times to influence what proteins are made at any one time.

  • Methylation is vital for this process, and therefore it impacts all the various processes within your body.

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Produces creatine and phosphatidylcholine.

  • Creatine is most well known in enhancing athletic performance, but there is now an increased focus on its role in it improving brain health and function due its ability in increasing brain energy.

  • Phosphatidylcholine is a precursor to acetylcholine, a neurotransmitter used to help sustain focus, learning, and to form memories.

  • Phosphatidylcholine is also a major component of cell membranes and is needed for healthy cell membrane function.

 

Neutralises and detoxifies toxins and hormones.

  • This includes foreign chemicals, heavy metals and oestrogen.

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Magnesium and B6 imbalances
Magnesium

Plays a role in over 300 enzyme systems in the body.

  • Making it influential in a great number of diverse biochemical reactions within the body.

 

Even due to just two of its roles, it impacts everything within your body:

  • It is needed to make proteins.

    • You have over 10,000 different proteins within you and everything within your body is either a protein or is made by proteins.

  • It is also needed for you to utilise energy.

    • Energy is needed for most things to happen within your body.

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It is commonly known for its relaxation affects:

  • It acts as an off switch to glutamate receptors.

    • This reduces the activity of glutamate which is a excitatory neurotransmitter, and at high levels is associated with: fear, anxiety, restlessness, disorganised attention, OCD, and insomnia.

  • It’s a cofactor in the production of serotonin.

    • The neurotransmitter associated with happiness and contentment.

 

B6

Has important roles in mental functioning.

  • With concentrations being 100 times greater in the brain than levels found in the blood.

 

This is because it plays an essential role in the production of a number of key neurotransmitters including:

  • Serotonin.

  • Dopamine.

  • GABA.

 

In addition to this it is involved in over 100 enzyme reactions and helps you avoid blood sugar dips by:

  • Releasing glucose from storage and converting amino acids to glucose when required.

 

Due to the above, deficiencies in B6 are associated with:

  • ADHD, lack of focus, and poor-short term memory.

  • Irritability and low energy.

  • Anxiety and OCD.

  • Depression and insomnia.

2. Nutritional / Biochemical Imbalances

3. The Metabolic Theory 

And your mighty mitochondria.

This puts forward that notion that mental disorders and neurological disorders are metabolic disorders of the brain.

  •  And metabolic dysfunction in brain cells can explain all the various symptoms experienced with these disorders.

 
In basic terms, metabolic disorders of the brain refer to your brain not getting enough energy to function optimally. 
  • Your brain requires vasts amount of energy - despite being only 2% of our body mass, your brain consumes 20% of the body’s total energy.​

    • ​In infants and young children, the brain uses up to 50% of their total energy, reflecting it's rapid growth and development.​

 
New research has highlighted the great importance of mitochondria in this regard.
  • This organelle historically had the sole aim of making energy within your cells, with issues leading to metabolic disorders.

  • Now it is known to have many other roles, many of which impact your brain's function.

 
This offers new treatment options.
  • These can focus on restoring metabolic health and improving mitochondrial function, which has a great knock-on effect on your brain health and function.

During our programme you will:​

  • Have the opportunity of receiving specialised tests to give you a more accurate assessment of your metabolic health.

  • Receive guidance on how to manage your blood sugar levels, helping provide a stable supply of fuel.

  • Understand the key nutrients for mitochondrial health, what can harm them, and how lifestyle factors can also increase their health and quantities.

  • Understand how exercise can impact your overall metabolic health.

  • Where necessary, ketogenic diets and fasting may be recommended to improve metabolic markers.

  • Not only will this improve your brain function, but your overall energy levels will improve, and you'll lower the risk of developing metabolic disorders such as type 2 diabetes, obesity, and cardiovascular diseases – conditions we see increasing greatly for all ages.

Please read below for a greater understanding on the role of energy and mitochondria function with regards to brain health.​​

Our brains are uniquely large and incredibly energy dependent
  • They are 6x larger than expected for an animal of our size and have tripled in size since the time we were apes.

  • Your brain has 86 billion neurons (brain cells) and over 100 trillion synapses.

    • Laid end to end these neurons would cover 180,00km in total length.

  • There are just as many support cells in the brain as neurons..​

    • These are called glial cells and they play vital roles in keeping the brain health and functioning.​

 

Energy within the brain is required to:

  • Make, regulate, and breakdown neurotransmitters.​

  • Fuel the actions of the other cells within the brain that aren't neurons.

  • Pass the good stuff into the brain, and release / keep out the bad stuff.

  • Control the immune system within the brain.

  • Help the neurons grow and reconnect to one another.

  • Repair and get rid of old and faulty cells.

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When there is not enough energy:

  • All aspects of brain cell function and health can be dysregulated.

Mitochondria - the powerhouse of the cell, but also much more...

Mitochondria are often referred to as the powerhouse of the cell.

  • They produce the lion’s share of energy for brain cells.

    • In a single brain cell, mitochondria produce 4.7 billion ATP molecules per second… and that’s at rest.

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In addition to their role in creating energy, new research has discovered that mitochondria also:

  • Are directly involved in the production, secretion and overall regulation of many neurotransmitters, as well as hormones such as cortisol, oestrogen and testosterone.

  • Regulate our stress responses.

  • Regulate our DNA expression.

  • Regulate our immune system.

  • Breakdown faulty areas within our cells so they can be replaced with healthy new versions to help ensure proper functioning.

  • Eliminate faulty cells.

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Therefore there are multiple ways that dysfunctional mitochondria could be contributing to limited brain health and function.

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Dysfunctional mitochondria are seen in those with brain issues

Dysfunctional mitochondria have now been implicated, and are often a key characteristic in neurological and mood disorders.​​

Dysfunctional mitochondria were primarily implicated in metabolic disorders, such as:

  • Type 2 diabetes, obesity and cardiovascular disease.

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This new understanding may explain why there is a very strong bi-directional correlation between mental health disorders and metabolic disorders.​

This is yet to be proven as correlation is not the same as causation, but mechanistically it makes sense due to dysfunctional mitochondria and the correlation's are striking:

  • Diabetes increases the likelihood of depression by 200-300%.

  • Weight gain around the time of puberty was associated with a fourfold increase in the risk of depression by the age of 24.

  • Obesity increases likelihood of depression or anxiety by 25% and bipolar by 50%.

  • 20% of those with heart attacks and 33% of those with congestive heart failure experience depression within a year of the event or condition.

  • Those with depression are 60 % more likely to develop diabetes and double the risk of having a heart attack by the age of 50.

  • Serious mental illness increases the likelihood of obesity three-fold.

  • Schizophrenia and bipolar disorder are 53% more likely to develop premature cardiovascular disease.

  • Children with autism are 40% more likely to be obese.

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Already the monoamine theory, from which the psychiatric system approach is currently built upon, is outdated. sufficeint flaws with drugs, more complex, more specific tools. sophistication

This focuses on the lack of neurotrophins within the brain.

These are a family of growth factors that include proteins such as:
  • Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), amongst others.

 

These growth factors regulate and play critical roles in:
  • The development, maintenance, survival, and function of the nervous system.

  • Neuroplasticity, neuroprotection and neurogenesis.

 

These processes are essential for:
  • Keeping your brain healthy and functioning.

  • Allowing your brain to adapt to new experiences or information.

 

A reduction in these neurotrophins and these processes are associated with:
  • Neurological disorders and poor brain function.​

During our programme you will:​

  • Learn how you can increase levels of these neurotrophins and their activity. 

  • Understand the other key variables that impact the neuroprotective, neuroregenerative and neurogenesis processes. 

    • This includes both diet and lifestyle factors.​

  • Learn how to limit neurotoxicity and neuroexcitotoxicity.​

  • Learn how you can maximise neuroplasticity to elicit changes in the brain that you are specifically desiring.

Please read below for a greater understanding and significance of the various processes that these neurotrophins influence.​​

The important balance between protective and harmful factors.

Your brain, when compared to the rest of the body, has a limited ability to repair and heal itself from injuries or insults.

  • If there’s sufficient damage to a neuron they will become dysfunctional and may die.

  • You don’t have the ability to regrow new neurons in the vast majority of areas within the brain, so maintaining these is paramount.

 

There is therefore a crucial balance between factors protecting neuronal health vs factors harming it.

Protective factors include:

Neuroprotection:

  • This is the process of preserving the neurons you currently have.

Neuroregeneration:​

  • The process of regrowth and repair of neurons.

Neurogenesis:

  • The process of producing new neurons.

  • This only occurs in the hippocampus, an important area of the brain involved in learning and memory, as well as your circadian rhythm.

  • Loss of hippocampal volume has strong associations with psychiatric and neurodegenerative conditions

  • Larger hippocampal volume is now being considered as a biological marker of resilience.

 

Harmful factors include:

Neurotoxicity:

  • The adverse changes in the structure or function of the nervous system from exposure to a chemical, biological or physical agent.

Excitotoxicity:

  • Damage made to neurons due to excess stimulation.

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Neurological disorders and mental health issues are associated with an imbalance in these factors. 

  • Contributing to poor neuronal function, damage and neuronal death.

The essential need of your brain to change - neuroplasticity

We need to make our brains adapt to the constant flow of different information in the changing outer world.

  • Each of your 86 billion neurons can have up to 30,000 connections to other neurons, and it is these connections that impacts how our brain functions, performs and responds to an experience.

  • These neurons need to be continually forming, eliminating, and modulating (strengthening and weakening) their connections in order to adapt to changing or new information.

  • This is essential for

    • Learning new information.

    • Developing various skills such as sustained focus.

    • Changing your thought patterns.

 

A great lie is that your brain is always changing, that neuroplasticity is always occurring, with new connections being made or removed.

Neuroplasticity reduces greatly as we age.

  • It’s why young children can learn multiple languages much easier and faster than adults.

  • The Kennard principle in neurology states that it’s better to have a brain injury earlier in life, because your brain is far more likely to recover and adapt when compared to being older.

  • This is also why we encourage those who are experiencing any negative brain symptoms to address these sooner rather than later to take advantage of this increased ability to change.

 

However, independent of age, we a see a lack of neuroplasticity and neurotrophins in those with neuropsychiatric and neurodegenerative conditions.

You have great influence over your brain's ability to change

There’s a much greater level of understanding for what’s needed to elicit neuroplasticity in the brain.

  • It is gated process because it is primarily controlled by neurotransmitters, particularly norepinephrine and acetylcholine.

  • Certain nutrients are required to ensure that the new connections are being made.

  • It occurs not during the experience but at a later time when your brain is in a relaxed state, and especially when you are sleeping.

 

This provides us with a number of behavioural, nutritional, and supplement-based tools at our disposal to help generate the change we are seeking.

These tools can:

  • Influence the neurotransmitter levels.

  • Provide the building blocks needed for the new connections.

  • Put you in a focused and alert state as well as switching you to a relaxed state.

  • Optimise your sleep.

4. The Neurotrophic Theory 

Allowing your brain to grow, heal, thrive, and adapt.

5. Neuroinflammation

The fire in your brain  and the critical role of your microglia.

Neuroinflammation is another new target of research for all brain disorders and optimal functioning.

Neuroinflammation is inflammation within the brain..
  • Short term inflammation (acute inflammation) is a natural and beneficial process evolved to protect our bodies from anything that might threaten it.

  • Chronic inflammation however, is known to cause or contribute to wide array of negative health implications throughout the body, with a growing understanding of its implications within the brain.

  • Chronic neuroinflammation is now being considered as a key pathological driver of many neurological diseases, due to its wide-ranging impacts.

 

There's a growing understanding of the role of microglia in neuroinflammation.
  • Microglia are immune cells found within the brain.

  • New research has discovered other important roles of microglia within the brain; providing a new treatment area which we can focus on as microglia activity can be through diet and lifestyle influenced.

During our programme you will:​

  • Test your own inflammatory levels.

  • Understand and have assessed your likely key triggers of inflammation.

  • Receive a dietary, supplemental, and lifestyle protocol to help lower your inflammation as well as improving the activity of your microglial; helping them improve your brain health rather than contribute to brain deterioration.​

Please read below for additional information on the impacts of neuroinflammation and the roles of microglia.​​

Acute vs Chronic Neuroinflammation

Just like in the body, the brain requires certain amounts of immune system activation and inflammation for vital roles, these include:

  • Protection of your brain from foreign invaders such as toxins or pathogens.

  • The disposal of:

    • Dead neurons.

    • Beta amyloid plaque - the substance that is thought to predispose one to Alzheimer’s disease.

    • Other cellular debris which can interfere with brain transmission and function.

 

Excess and chronic inflammation within the brain can have devastating results, such as:

  • Limited energy production in the cells.

    • Resulting in brain function and endurance dropping.

  • Hindered communication between neurons.

    • Leading to neurons firing more slowly and thus slowing down brain function further.

  • Altered neurotransmitter activity.

    • For example tryptophan, a precursor to serotonin, ends up producing a neurotoxic substance rather than serotonin. 

  • A breakdown of the blood brain barrier as well as limiting detoxification within the brain.

  • Over the long term this can lead to:

    • The damage and death to many neurons which ultimately leads to reduced function and neurodegenerative diseases.

The great importance of microglia.
The immune soldiers and architects of the brain

They originally thought these cells merely were the glue holding the brain together.

  • Glia is the Latin word for glue.

 

Recent research shows these play a vital function in our immune function.

  • They are the most prominent immune cells in our central nervous system.

  • This makes them vital in completing the immune functions within the brain.

 

It was discovered that they also play a significant role in the development and structure of the brain.

  • They regulate neuroplasticity by trimming and pruning synaptic connections.

  • They regulate neurogenesis, which is the growth of new neurons.

  • They are crucial for the maintenance of myelin, which helps nerves communicate with one another in a rapid fashion.

  • They release BDNF which is a growth factor within the brain.

 

Microglial have different phenotypes and can either be promoting brain health or brain deterioration.

  • In their M2 phenotype they:

    • Promote neuroprotection and neuroregeneration activities and processes.

    • Help lower, and can help calm down levels of inflammation in the brain.

  • Their M1 phenotype can lead to:

    • Them becoming overzealous and creating excessive neuroinflammation and oxidative stress.

    • Resulting in the previously described issues of neuroinflammation.

 

Helping ensure your microglia are expressing the right phenotype can go a long way in improving your brain health and function and is an area of strong active research.

  • Pharmaceutical companies are now focusing on drugs that influence microglia activity and neuroinflammation, but there is already so much that can be done from a diet and lifestyle point of view.

Already the monoamine theory, from which the psychiatric system approach is currently built upon, is outdated. sufficeint flaws with drugs, more complex, more specific tools. sophistication

Most people think of your gut as one long twisting garden hose.
  • One that extends from your mouth to your anus.

  • That is in charge of absorbing the key nutrients from the foods we eat.

 

Fairly simple right?

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However, what happens within this tube and what passes through it is a vast area of research, due to its growing complexity and wide-ranging impacts.
  • As Hippocrates said nearly 2500 years ago “All disease begins in the gut.” 

 

The gut-brain axis refers to a strong bi-directional link between the gut and the brain.
  • Ongoing research is discovering new and multiple mechanisms at play.

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The gut can influence the brain via:
  • It’s ability to fully breakdown the nutritional components from the food we eat.

    • This allows them to be absorbed into the body, helping provide the energy, building blocks, and cofactors needed to run all the processes within the brain.

    • Certain compounds in ‘healthy foods’, if not broken down or dealt with correctly can cause significant issues when passed into the body and brain.

      • Certain proteins from dairy and gluten have been shown to have:

        • Morphine like affects in the brain.

        • Contributing to issues such as irritability, aggression, moodiness, anxiety & depression.

        • As well as problems with learning, following directions, speech and hearing.

  • Keeping out pathogens, toxic substances, and waste products.

    • Within the body these compounds can have wide ranging impacts and may be able to pass into the brain.

    • Waste products from the body include hormones, which can be reabsorbed if the gut isn’t functioning appropriately, leading to hormonal imbalances.

  • Greatly influencing the immune system.

    • It impacts your food allergies and intolerances, inflammatory processes and autoimmunity.

    • It is often the largest source of inflammation within the body.

    • This can then travel to the brain and make your blood brain barrier leaky as well as triggering neuroinflammation.

  • Sending signals to the brain via the vagus nerve.

    • The vagus nerve is the longest nerve extending out from the brain, and travels from the brain stem, through numerous organs, including your heart, lungs, liver, your gut, and terminates at your abdomen.

    • Depending on what you have eaten and the state of your intestines, signals can be sent from the gut to the brain via this nerve which can:

      • Trigger stress and neuroinflammation,

      • Engage the hypothalamus and limbic system – areas responsible for the regulation of emotions.

    • The brain can equally send signals to the gut, impacting gut functions.

  • Producing neuroactive compounds.

    • These include some of your key neurotransmitters which can travel to the brain via the blood, or stimulate signals in the brain via the vagus nerve.

 

Your gut microbiome has been shown to be a critical factor of your gut health and is an area undergoing extensive constant research.
  • Changes in your microbiota are present in almost every disease state.

  • There is mounting evident in determining how gut microbiota can contribute to neuropsychiatric and neurodevelopmental disorders as well as your general mood, behaviour, cognition, sleep and even appetite.

  • A snapshot of some of the important microbiome findings have been listed further below.

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There are many different organs and processes involved in your overall gut function, resulting in many areas where problems can arise.
  • From the digestive glands in your mouth, your stomach acidity, your liver, pancreatic and gall bladder function, the integrity of your small and large intestine as well as your overall microbiome.

  • Many different factors impact the overall functioning of these organs and process.

  • As a result no two people have the exact same response from their diet and it's important to work out what works best for you and your body.

During our programme you will:​

  • Have your overall gut health assessed through symptoms and questionnaires, as well as being given the option for specific gut tests which can provide detailed insight on the overall function of your gut and the composition of your gut microbiota.

  • Learn and assess which foods may be problematic for you, with options for additional testing on food intolerances or the presence of certain peptides which are known to cause neurological issues.

  • Clear dietary and lifestyle advice with the aim of giving you as much dietary freedom as possible, yet recognising when important dietary restrictions may be required for certain periods.

Please read below for a greater understanding of your microbiome and just how influential it can be. ​​​

The microbiome overview and it's impact on your digestion and metabolic function

Your gut microbiota is:

  • The community of microorganisms that live within your gut, ones we have co-evolved with over thousands of years.

 

This predominately includes bacteria, but also fungi and viruses.

  •  Recent estimates is that you have 38 trillion bacterial cells in your gut, this equates to 1.3 bacterial cells for every human cell.

  • Collectively these microbes have around 3.3 million genes, or about 100 times the number of human genes that we have

    • The genetic potential of these microbes is enormous.

 

There’s been an explosion in microbiome research in the last 20 years

  • The microbiome wasn’t recognised by modern scientists until the late 1990s.

  • Today, laboratories all over the world are studying the microbiome and its implications on our health.

  • In 2019, there was 2,400 clinical trials testing microbial therapeutics.

  • There is still much to be discovered, but some important roles have also been identified.

​

Its impact on your digestion and metabolic function:

  • The microbes breakdown fibre and can synthesise a number of vitamins including K2, B12, riboflavin, niacin, and folate.

    • Many of these have influential roles on brain health and function.

  • They also produce short-chain fatty acids (SCFAs) such as butyrate. These have been shown to:

    • Fuel your intestinal cells – providing 60-70% of the energy requirements.

    • Suppress gut inflammation and help regulate the immune system within the gut.

    • Improve gut barrier permeability by accelerating assembly of tight junction proteins.

    • Improve insulin sensitivity, increase energy expenditure, and reduce adiposity.

    • Animal studies have shown they can increase:

      • Neurogenesis, BDNF, and serotonin within the brain.

  • They can affect your digestion and influence your blood sugar response from food as well as how many calories are extracted from your food.​

How it influences your immune system and
intestinal permeability

70% of your immune cells are found within your gut.

  • They lie just under a 1-layer thick layer of gut cells, separating them from the outside world.

  • Your gut microbiota lies on the other side of these gut cells and are technically considered outside of your body.

 

Our gut microbes play crucial roles in the development and regulation of the immune system, by being in constant communication with one another.

  • The immune cells are constantly “sampling” microbes and dietary proteins in the gut.

  • These samples are presented to other immune cells which influence whether they trigger an immune response or not.

  • This affects whether you have reactions to certain foods or not, or whether a strong immune response is needed to protect against any potential pathogens.​

 

What is intestinal permeability / leaky gut.

  • As previously mentioned, the immune cells in your gut lie behind just a thin, fragile lining of only one cell thick gut cells.

  • If this lining becomes damaged or compromised, gaps can open up between these cells, resulting in compounds sneaking into the body and your blood stream that are meant to be kept out.

  • This can lead to your immune cells reacting to these compounds, as well as these compounds travelling around the body and brain causing negative impacts.

 

Leaky gut can cause numerous negative impacts due to these compounds interacting with the immune cells:

  • You can become allergic or have food reactions to foods that you previously were fine with.

  • You may become sick more easily.

  • You may develop autoimmune issues.

  • Your immune system can become overactive, resulting in your body becoming overrun with inflammation which can:

    • Disrupt blood brain barrier, which is why they say a leaky gut equals a leaky brain.

    • Cause neuroinflammation.

    • Cause imbalances on various hormones.

    • And much more.

​

Although many factors can influence your intestinal permeability, your gut microbiota plays an important role due to various mechanisms including:

Positive roles:

  • Acting as a physical barrier to pathogens toxins.

  • Helping gut cells produce mucous which also acts as a physical barrier.

  • Providing gut cells with the energy to close these gaps and becoming less 'leaky'.

Negative roles:​

  • Contributing to leaky gut due to dysbiosis and causing inflammation within the gut.

  • They can also produce endotoxins which can pass through the gaps and are pro-inflammatory within the body as well as being associated with anxiety, depression, and cognitive deficits.

​

It's therefore no wonder that a disrupted microbiome has been connected to:

  • Allergies, autoimmunity, and virtually every other chronic inflammatory disease in which it has been studied.

They secrete neuroactive compounds that have psychiatric properties.

These properties can impact your:

  • Mood, behaviour, cognition, sleep, and appetite.

 

Certain bacterial species can produce some of your key neurotransmitters, such as:

  • Serotonin, dopamine, GABA, and acetylcholine.

 

They can also influence your gut cells to produce these neurotransmitters.

  • With 95% of serotonin and 70-80% of dopamine being produced in the gut

 

They can also stimulate other gut cells to produce neuropeptides.

  • These can travel to the brain via the blood or stimulate signals up the vagus nerve, thus influencing the brain.

 

They have been show to affect BDNF levels within the brain.

  • Influencing the development, maintenance, survival, and function of the nervous system.

6.The Gut-Brain Axis

How your gut influences your brain,
and how your brain influences your gut.

7. Hormones 

Impacting the brain as well as the body.

Hormones are chemicals that play crucial roles in controlling and coordinating many different functions within your body.
  • By carrying messages through your blood to your organs, skin, muscles and other tissues.

 

There is a growing understanding on the various ways these hormones are impacting brain health and function.
  • Not only do these hormones affect functions in the body that can influence the brain, but there are also many hormone receptors in the brain where these hormones have a direct affect.

  • Most of the hormone activity in the brain originates from hormones in the body which pass into the brain.

  • However the brain also produces a number of hormones itself, highlighting the importance of these on the brain’s function.

​

With growing numbers of people having hormonal imbalances, this is another key area of our treatment plan that be can focused on.

During our programme you will:​

  • Have your hormones assessed from your presenting symptoms and questionnaire discussions.

  • Have the opportunity to test your hormone levels with lab tests, ones that are more advanced than the standard GP hormone tests.

  • Specific guidance on dietary, supplemental, and lifestyle practices to correct for any hormonal imbalances and options to retest your hormone markers to help monitor progress.

Please read below for a greater understanding on how some of your hormones can influence your brain function.​​

Cortisol

This is considered your primary stress hormone.

​

Although stress can be beneficial in short bursts, chronic stress can be highly detrimental.

  • It initially leads to sustained elevated cortisol levels.

  • This can progress and switch into sustained periods of low cortisol.

  • Both have a negative impact towards the brain.

 

Issues of sustained elevated stress levels:

  • Disrupted sleep is normally the first thing we notice.

    • This could be trouble falling asleep or staying asleep.

    • This alone has significant negative knock on effects on the brain.

  • Causes atrophy of the hippocampus, an area involved in learning and memory.

    • You may start being more forgetful and struggle with concentration and making good decisions.

  • Effects the limbic system of the brain making it trigger the sympathetic fight or flight response more easily.

    • You therefore find yourself overreacting to more mundane incidences.

    • You may become irritable and always feel in a “high alert” state.

  • Cortisol suppresses immunity so you are more susceptible to infections.

  • Lowers other hormones such as thyroid hormones, growth hormone, and your sex hormones.

    • This impairs growth, repair and reproductive functions.

    • These hormones also have direct impacts in the brain themselves.

  • DHEA is lowered which is considered the "fountain of youth hormone".

  • Your digestive system will be inhibited.

    • Resulting in poor digestion and absorption of nutrients.

    •  You may feel poor digestive symptoms such as heartburn, bloating, or constipation as a result.

 

Issues of lowered cortisol levels:

  • Fatigue, particularly on waking. 

    • It’s normal to have a bump in cortisol to wake you up and to get you going in the morning, so without this increase you often feel lethargic.

  • Similarly small bursts of cortisol help you deal with daily stressors.

    • So now your ability to deal with problems is minimised.

  • Cortisol has an anti-inflammatory role, so inflammation can become excessive.

    • Leading to wide ranging issues including neuroinflammation.

  • Cortisol is also needed to increase your blood glucose levels when they are running low.

    • This can result in low energy, irritability, poor focus and motivation, and general reduced brain function.​​

Sex Hormones

Unfortunately both sexes are increasingly struggling with sex hormone imbalances.

  • Women with premenstrual syndrome (PMS) and those struggling with perimenopause are on the rise, and female infertility is at an all-time high.

    • Mood issues associated with PMS and perimenopause give a clue that these hormones greatly influence the brain.

 

  • Men are increasingly also suffering from imbalances:

    • Men today have much less testosterone compared to a man of the same age a generation ago.

      • Levels are dropping at an average of 1% from 1987, meaning that in 2024, men have 37% lower testosterone.

    • Erectile dysfunction has also doubled in the last 25 years.

 

Sex hormone roles go far beyond sexual function, and are important factors in boosting mood, cognition and handling stress and uncertainty:

  • They can influence neurotransmitter activity by having powerful effects on receptor sites:

    • Oestrogen impacts serotonin, dopamine and acetylcholine receptors.

    • Testosterone impacts dopamine and acetylcholine receptors.

    • Progesterone impacts GABA receptors.

  • Many of these receptor sites are found in the frontal lobe.

    • This area of the brain is what distinguishes us from other animals and much of our personality and who we are stems from this area.

    • It also impacts our ability to reason, suppress impulses, and regulates are emotional drive and motivation.

  • Sex hormones even affect the shape and structure of the brain

    • Anatomically men and women have slightly different brains.

    • When people undergo sex changes using high amounts of sex hormones, this has been shown to change the structure of the brain, a powerful testament to the influence of these hormones on the brain.

  • Progesterone has been shown to be a powerful modulator of the brain’s microglia cells.

    • Helping dampen neuroinflammation when necessary.

Thyroid Hormones

Thyroid hormones are best thought of as controlling your metabolic rate.

  • This is how much energy your body is using.

  • Every cell in your body - including your neurons - is impacted by thyroid hormones, influencing how much energy they can use and therefore how much activities and functions they can accomplish.

​

Due to this and for other reasons, thyroid hormones greatly impact the brain.​​​

  • Adequate levels are essential for the normal growth and development of your central nervous system.

    • They influence neurogenesis, creation of synapses, and myelination.​

    • They are needed for neuronal and glial cell differentiation within the brain.

    • They regulate a large number of genes within the brian​​

  • They play a vital role in dampening brain inflammation.

    • By having a direct effect on your microglia cells.

  • They impact neurotransmitter activity.​

    • Low thyroid levels can decreases many neurotransmitters including: serotonin, acetylcholine, GABA, and dopamine.

    • For neurotransmitters to work effectively, the health of the synapse is important, and thyroid hormones greatly influence this also.​

​

As a result, thyroid hormone imbalances can impact all aspects of brain health and function.

 

The most common symptoms of low thyroid are:

  • Depression.

  • Fatigue.

  • Brain fog.​​

8. Social and Psychological factors

Key factors that can directly impact the physiology and function of the brain and body.

With our greater understanding of the brain’s inner workings, we are now understanding how social and psychological factors are directly impacting your brain’s physiology, health, and functioning.

 

All our organs can still thrive without interacting with others, all except the brain.
  • During our long history, we could only survive by working together with others and living in close groups.

​

Our brains were hardwired with certain psychological and social needs, to help ensure our survival and ability to thrive.
  • Some examples are:

    • Safety and security.

    • A sense of community.

    • Challenge, achievement and goals / a purpose.

    • A strong identity and a safe space in which to assert it.

 

It’s clear times have changed dramatically since our hunter-gatherer times, and the way in which we live.
  • For the first time in our history, due to the technological advancements, it's possible to survive without interacting with others face-to-face and never actually having to leave the comfort of your home.

  • We can work remotely, contact our friends remotely, and can get anything you want delivered to your door.

  • Our sense of community is dropping and we are in the midst of a loneliness epidemic.

  • Work hours are on the rise, and work can always follow you around via your phone.

  • We are bombarded with information constantly, much of which is details of the worst things currently happening in the world, or other information written to elicit fear and worry.

  • Chronic stress seems nearly ubiquitous, little time is spent outdoors, and time spent indoors is dominated by looking at screens. 

 

Our genes and hardwiring have not adapted to these rapid changes.
  • Some of our core psychological and social needs aren't being met.

    • This can cause disruption and negative impacts to your brain’s physiology and overall function.

 

When we successfully meet these needs:
  • It brings about positive changes in our physiology.

​

Many in the pursuit of health ignore these psychosocial factors.
  • This is a mistake.

  • By becoming aware of how these factors impact your physiology, we hope this gives you the incentive to prioritise these factors.

During our programme you will:​

  • Have some of these key social/psychological factors assessed and learn how these can both positively and negatively impact your overall functioning.

  • Receive guidance on how to improve these factors directly.

  • Be provided with nutritional or lifestyle practices which can also mitigate the impacts of these factors on your brain’s underlying physiology.

Please read below for some examples of how these factors can impact your physiology and function.​​​

Loneliness and Connection

From an evolutionary point of view, being part of the tribe was a non-negotiable:

  • Being away from your tribe was a death wish; you relied on the strength of the group for your protection and resource acquisition.

  • If you weren’t interested in that bond with others, or if you were kicked out of the group, you wouldn’t survive very long on your own.

  • This togetherness was so essential for our survival that our bodies have built into them these hardwired systems to help maintain and incentivise you to stay close with others, and to punish you if this isn’t happening.

 

How having a strong sense of connection to others impacts your physiology:

  • Increases serotonin.

    • Serotonin is often called the happy hormone as it increases the likelihood of brain circuits activating in the brain which generally give us a feeling of wellbeing and contentment.

    • But it also helps our immune system and has other functions which are known to buffer against the bad effects of stress, particularly in the brain.

  • Blocks tachykinin.

    • The body secretes higher levels of tachykinin when we are not socially connected enough.

    • It is a neuropeptide and is implicated in stress mechanisms, mood and anxiety regulation, as well as emotional processing.

    • This molecule makes us more irritable, fearful and paranoid, and increases that sense of loneliness.

  • You can think of these as your body motivating you with the carrot and stick method:

    • Serotonin being the carrot and tachykinin being the stick.

  • A study from the University of Harvard has shown that:

    • The biggest indicator of long-term health and well-being is the strength of your relationships with family, friends and partners.

  • A different study suggested that:

    • Loneliness has the same impact on mortality as smoking 15 cigarettes a day, making it even more dangerous than obesity.

​

This is all particularly concerning given our modern society is suffering from an epidemic of loneliness.

  • Work at the University of Oxford shows 35% of young people are reporting high levels of loneliness.

  • 45% of adults in England feel occasionally, sometimes or often lonely in England.

  • A survey in the UK found that for men:

    • 27% reported they don’t have any friends at all.

    • 38% never organise to see their friends for drinks of food.

    • 47% do not talk openly with friends about their problems.

 

Improving your overall health and brain function:

  • Can help you have the energy, confidence, and motivation to improve your social connections.

  • It can also limit some of the negative impacts associated with a sense of disconnection to others.

 

But recognising the importance and prioritising social connections is important.

  • It’s easy and normal for social connections to slip away from you due to the demands of life.

  • Understanding the importance of these can help you prioritise and schedule your time to ensure that you don’t slowly lose your connections to those close to you, as well as increasing connections with new acquaintances.

  • The health benefits of a greater sense of community not only makes you feel good, but also improves your productivity in work, increases your energy and reduces the risk of many health concerns.

Purpose and Meaning

"He who has a why to live can bear or deal with almost any how” - Friedrich Nietzsche.

 

An extreme example of this is Viktor Frankl’s book “Man’s Search for Meaning”.

  • It is his account of his experiences as a prisoner in Nazi concentration camps during world war 2.

  • He was able to survive 4 different concentration camps and his main observation was that the prisoners who tended to survive had some sort of future-orientated goal, or found meaning in their suffering.

  • Prisoners who were less likely to survive found their suffering meaningless, had no reason to survive, and their bodies and minds tended to give up on them at a much more rapid rate.

 

Although this is an extreme example, there's good evidence that having some sort of meaning and purpose is incredibly important for our everyday lives.

  • This could be providing for your family, pursuing a passion, serving others or contributing to society.

 

The negative impacts for not having this tends to be higher for men than women.

  • Studies show that the effect of unemployment on mental health is twice as strong for men than women.

  • Being made unemployed is a significant stress to a man, and low job security can be seen as a chronic stress to them.

  • Studies even show that after retirement – indicating a loss of purpose and self-identity - men's depressive scores actually worsen, whereas there’s no difference when women retire.

  • Evidence suggests that divorce and romantic breakup are strong risk factors for mental illness and suicide.

    • Again, this has a greater impact on men than women with one study showing that men are roughly twice as likely to report depressive episodes in the 2 years following a divorce than a divorced woman.

​​

Developing goals and working towards some future state can improve our health and functioning.

  • Progressing towards a goal makes us feel good and motivated.

    • This is due to dopamine being released throughout this process.

  • Although completing a goal also releases dopamine and makes us feel good, these good feelings are often short lived and it’s only when we start working towards something else that we get back to feeling good and motivated.

Stress 

Most people think of psychological stress when they hear the term stress.

This can be anything from:

  • Challenging relationships, social expectations, bereavement.

  • Juggling responsibilities and financial challenges.

  • Being concerned for others or factors going on in the world.

 

These psychological or stressful events are often called “perceived” stressors.

  • This is because it is the perception the individual has about the event which determines how stressful they find it and therefore the magnitude of the stress response.

 

Therefore there’s a huge individual variance on what people find psychologically stressful.

  • For what one person may really enjoy, another may find excruciatingly stressful.

  • In fact the brain can’t even tell the difference between imagination and reality.

    • Imagining a threat lights up the same regions in the brain compared to experiencing it in real-time.

  • "The mind is its own place, and in itself can make a Heaven of Hell, a Hell of Heaven” - John Milton.

​

There are plenty of other, non-psychological sources of stress such as:

  • Poor diet: blood sugar spiking, inflammatory foods, etc.

  • Illness: insulin resistance, digestive issues, infections, etc.

  • Circadian rhythm disruption.

 

These all trigger the stress response system.

  • This response is very generic, no matter what the original stress-inducing stimulus.

  • You can think of having a stress bucket, and all these different stresses can add to this bucket.  

  • They all have an accumulation effect on your stress response.

 

Excess stress can cause numerous issues within our body and brain.

  • Many of these have previously been described in the hormone section, with the issues of cortisol – your main stress hormone – being described.

​

It’s therefore important to understand the full breath of stressors you are facing.

  • These can then be addressed by a variety of tools and strategies.

  • For example, working on improving brain health tends to decrease psychological stress as your brain is able to be more resilient and can think more clearly in stressful situations.​

Trauma

Traumatic events have been shown to increase the risk of numerous health issues including:

  • Mental health and mood disorders.

  • Cancer and heart disease.

  • Autoimmune conditions and Multiple Sclerosis.

​​

The mechanisms for why these events can be so problematic are now better understood.

They have been shown to have a wide variety of effects within body, some of which can last for many years. These include:

  • Epigenetic changes:

    • Changes in which parts of your DNA are expressed.

    • This can affect many different functions, but particularly we see changes in how the brain response to stress.

  • Hormonal changes:

    • Long-term increases in cortisol and adrenaline levels.

  • Neurologic changes:

    • Neurotransmitter and receptor dysregulation.

    • Neurotoxicity of the hippocampus.

    • Hypothalamic-pituitary-adrenal axis dysregulation.

    • Stimulates neuroinflammation and microglia activation.

  • Immunologic:

    • Increased inflammatory markers and inflammatory mediators.

    • One study showed that childhood abuse was associated with various markers of inflammation being higher, even 20 years later.

 

These mechanisms tend to impact children to a greater degree.

  • They are emotionally less mature and the brain is physically still developing.

  • Therefore some of these changes can be more permanent as their brain’s hardwire them as they develop.

​

We can’t always go back in time to prevent these events from occurring but we can:

  • Address these negative physiological changes which have occurred as a result.

    • For example in rat studies, where rats where experiencing trauma like behaviour, when the microglia were inhibited, the trauma behaviour went away.

    • Drug companies are trying to develop drugs that do this purpose, but we already have nutritional and lifestyle tools to lower microglia activation and neuroinflammation.

  • Build up your own stress resilience and stress tolerance to make you best equipped to handle any future life challenges and reducing the negative impact of these.

Technology has also become insidious in our lives, radically changing the way in which we live and socialise.

  • Below describes a few ways in which technology is impacting our lives. 

  • Understanding these impacts and being able to enhance the benefits of technology, whilst limiting the negative impacts is an important part of our programme.

Addiction, loss of focus and motivation. 

Video games, apps, online platforms are addictive by design, not by accident.

  • The business model of most of these platforms is based on engagement.

    • Their metric of success is not money but minutes.

    • Your time and attention is their commodity, the more that these rise, so do their advertisement sales.

    • There’s a reason Silicon Valley calls its customers “users”.

  • Behind the code lies many influential behavioural psychologists who help design the experience in such a way to keep you engaged and staying on the platform.

 

Primarily they are influencing your actions via influencing your dopamine levels.

  • The likes, the shares, the novelty, the levelling up in games, all of these are designed to make you release dopamine.

 

Dopamine has more of a motivational effect, rather than purely a pleasurable effect which is often depicted.

  • It reinforces whatever behaviour led to that dopamine hit.

  • Have you ever just wanted to check just one thing on your phone, and then suddenly 10 minutes go past like a flash.

  • The creator of the infinite scroll estimates that it induces the average user to spend 50% more time on platforms like Instagram - he has come to regret his invention.

 

This can also create a craving for the behaviour that led to the dopamine release.

  • Even if you’ve just checked your phone, do you find yourself itching to reach for it again and to check your favourite social media sites, emails, or favourite apps.

  • You may even find yourself automatically reaching and getting your phone out, without any conscious thought.

 

The immediate downside of this is high distractibility, and an inability to keep our focus on a specific task.

  • This has obvious professional and career implications, but it can also greatly harm personal relationships.

  • This issue is particularly concerning for children and teens.

    • This is because their brains are still developing.

    • Much of their later development is in their prefrontal cortex where they learn sustained concentration and how to stop distracting impulses.

    • By not learning this skill as their brains are developing, this inability to sustain concentration can continue into adulthood.

 

This can develop into a narrowing of focus, motivation, and enjoyment throughout various aspects in life.

Our brains are highly dynamic and can adapt to given stimulus.

  • The constant dopamine spikes caused via this technology leads the brain to down-regulate the dopamine system.

    • You may lower the sensitivity of your dopamine receptors, or even the number of receptors.

    • In addition your baseline dopamine may drop.

  • This can lead to a narrowing of focus, motivation, and enjoyment throughout your life.

    • Areas where it was challenging to sustain focus become much harder.

    • Even the rewarding activities can become boring.

  • This overall lowered sense of motivation often results on you focusing more times on the areas which still give you that dopamine hit.

    • These are the technologies that got you into the problem in the first place.

    • Unfortunately this only compounds the problem.

Fear, anxiety, stress and divisiveness.

​We see that as social media use rises, as do anxiety levels, particularly in girls.

This can be for many reasons, some of which are:

  • With more and more time spent on social media it’s common for people to constantly compare their lives and themselves to others.

    • Being connected to lots of people can easily give the impression on your feed that people are having a great time all the time, partly because most people tend to share their highlights or successes.

    • It also doesn’t help that filters and editing software is used to make both the people and the experience look better.

    • Now that we are connected to the entire world, there will always be someone who trumps you on a given characteristic which can lower your self-esteem even if you are doing great.​

    • “Comparison is the thief of joy” – Theodore Roosevelt

  • It can take moments away from your own good times and memorable experiences.

    • Due to the need of having to 'capture the moment' so you can put it up on your social media.

    • This ironically stops you from embracing these moments to the fullest.

  • Popularity and connections are now fostered partly online.

    • Many are anxiously checking their engagement following posts, always desiring more likes and positive comments.

      • This can occur throughout the days/weeks, pulling them out of focus of whatever they are doing, and having that underlying urge to recheck their engagement.

    • It also doesn’t help that it’s normal for us to completely focus on any negative comments and to ignore the positive ones.

  • The 24/7 nature of these technologies means that the above issues can always be occurring.

 

The attention economy leans on triggering your negative emotions to keep you engaged.

With the rise of digital devices, information overload, and our finite attention, the attention economy refers to the fact that many companies recognise that the world’s most valuable currency is actually our attention, and they will do whatever they can to try and capture it.

  • Using fear to keep us engaged.

    • Our feeds are controlled by algorithms designed to keep you engaged and to scroll for longer.

    • They have reinforced what great orators have always utilised:

      • Invoke fear and your audience will be completely engaged.

    • Fear creates clicks, views and shares.

      • This is because it exploits the primal nature in us, an evolved sensitivity to threat.

      • This triggers our amygdala in our brain, which causes our body to release the stress hormone cortisol.

    • This has been known for some time in the news space; “if it bleeds, it leads”.

      • Flicking through news sites, articles, and programmes, is basically getting bombarded with worst possible things happening throughout the world at that moment.

    • Another adage to keep in mind is “bad news sells”.

      • Misleading and hyperbolic headlines are used to exaggerate our perception on what is actually going on.

    • This constant fear can easily build up our anxiety levels, as we are only focusing on the most extreme and negative factors, and don’t take in all the good that is happening.

      • It’s important to remember that we’ve evolved from hunter-gatherer times.

      • Our brains aren’t evolved to take in and process all this information in a healthy manner.​

  • It’s not just fear that is used, controversial and extreme content is also shared.

    • These algorithms don’t have morals behind them and they’ve learnt that it’s easier for us to disengage from calm and positive content.

    • Negativity bias states that negative experiences impact us more than positive ones, enticing us to stay engaged on the relevant platform

    • Once again this can increase our stress, but it also increases our divisiveness.

      • Facebook conducted an internal investigation called “Common Ground” and found that “our algorithms do exploit the human brain’s attraction to divisiveness”.

A loss of connection in the hyper-connected world

It seems ironic that we’re experiencing an explosion of chronic loneliness across the world, which has coincided with the development of technology, like social media, that is meant to connect us.

​

Psychologists explanation is that social media facilitates communication, but not real connection.

  • Connecting face-to-face stimulates all your senses, whereas with a screen this is mediated through a series of pixels – a new form of communication that our brain’s old wirings don’t quite respond to in the same way.

  • It may scratch an itch temporarily, but communication over a screen doesn’t lead to that long-term sense of well-being.

  • With the growing trend towards more communication being facilitated over technology and not in person, these issues are likely to only get worse.

A reduction in play

It has been put forward that perhaps the most nutritious thing a child/teen can do is hang out and play with other children.

  • Play also shouldn’t stop at adulthood, as it has been shown to also have many benefits for adults.

 

The rise in technology has dramatically reduced in-person play as children and adults spend more time on:

  • Communicating or scrolling on social media.

  • Playing video games or watching shows.

 

The importance of play for children:

  • Humans are born with very large brains.

    • These take many years to fully develop and adapt to the world in which we live.

  • Play is a vital process in this development.

    • Play creates the optimal developmental milieu to prepare children: mentally, emotionally, socially and physically for the experiences and challenges of life.

  • Play has been recognised by the United Nations High Commission for Human Rights as a right of every child.

    • Highlighting just how crucial it is for child development.

 

Play is also associated with many positive behaviours and skills that enhance the quality of life of adults, as well as children:

  • Creativity, productivity, flexibility, optimism.

  • Empathy, cooperation, problem solving.

  • Increased resilience in dealing and managing with stress, as well as decreasing the health risks associated with isolation and loneliness.

  • Helps forge social connections and creates a sense of community and belonging.

​

Play also helps maintain a healthy brain.:

  • It increases BDNF; the protein that helps the growth, differentiation, survival of neurons, and establishes neuronal connections in the prefrontal cortex – a brain area involved with cognition and emotion.

Less exercise 

Our increased use of technology and screen times is also reducing the amounts of general exercise we do.

​

Few interventions match the general benefits of exercise for brain health and function.

This can be demonstrated by the remarkable recent findings on exercise and its impact on depression:

  • Exercise was shown to be 1.5 times more effective than the best antidepressants.

  • There is a dose related response in exercise and its ability reducing the risk of getting depression.

    • Compared to those who did not exercise, people who got half the recommended volume of physical activity lowered their risk for depression by 18%.

    • Those who got the recommended amount lowered their risk by 25%.  

  • It was estimated that 11.5% of depressive cases could have been prevented if recommended activity levels were met.

 

What’s great about exercise is that it is improving your brain health through a variety of mechanisms, many of these have been expanded upon in the other sections:

  • Increases serotonin levels.

  • Lowers kynurenine.

    • Which is associated with less stress and improved mood.

  • Increases endorphins which also boosts mood.

  • Increases brain-derived neurotrophic factor (BDNF).

  • Anti-inflammatory effects.

  • Increased testosterone.

  • Improves metabolic health / insulin resistance.

    • This also goes a long way to improving longevity.

    • One study found that hitting the recommended amount of exercise reduced cardiovascular disease death by 34% and 44% for men and women respectively, as well as reducing all cause mortality by 36% and 55%.

Less sleep

Increased screen time, particularly evening use, is also reducing our sleep.

  • The average sleep time an adult gets each night is an hour less than it was at the beginning of the 20th Century.

  • For children, the lost sleep time is an hour and 25 minutes.

  • Almost 1 in 5 people in the UK aren’t getting enough sleep.

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Sleep is an essential for optimal brain health and cognition.

 

Sleep deprivation results in the following:

  • Your brain can’t make new connections.

    • These connections are made when you are sleeping and are used to embed what you have learnt throughout the day.

  • Your brain doesn’t store information in its long-term memory.

    • During sleep, your brain moves your experiences into its long-term storage.

  • Your brain can’t cleanse itself.

    • The brain is very active during the day and this builds up a lot of waste material.

    • While you sleep, the cerebrospinal fluids washes in and out of your brain, helping get rid of this metabolic waste.

  • Your brain can’t dream.

    • Dreaming helps you process the emotions you felt during the day without triggering stress hormones.

  • Your amygdala becomes more reactive.

    • This is the part of the brain that controls emotion.

    • This leads to 60% more emotional reactivity.

 

This sleep deprivation can result in:

  • Worsening of your attention and concentration.

  • Worsening of your emotional control.

  • Increased risk of Alzheimer’s disease.

 

It also disrupts many normal physiological processes and can contribute to:

  • Heart disease, diabetes, obesity, weight gain.

  • Reduced reproduction (by affecting hormones), athletic performance.

  • Ageing and death.

 

If you could bottle the benefits of sleep into a pill, it would be by far the most popular pill on the market.

Countryside Road

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About

Hear about the founder's personal story and experience that led to the development of the Peak Brain Health Clinic.

Child Enquiries

For more information on which conditions are covered for children, what to expect, and the benefits available to them.

Adult Enquiries

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Programme Process

Gain a clear understanding of the various options available to you at the clinic and the stages involved.

Programme Approach

Discover the in-depth nature of our approach and how it sets us apart from other forms of treatment.

Limitations of Conventional Medicine

Discover the limited effectiveness of psychiatric medications, their risks, as well as the reasons behind these.

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